ELISA SPAG5 anti-

Quantity :50µL Clone Number: Aliases:Astrin antibody; Deepest antibody; hMAP 126 antibody; hMAP126 antibody; MAP 126 antibody; MAP126 antibody; Mitotic spindle associated protein antibody; Mitotic spindle associated protein p126 antibody; Mitotic spindle coiled coil related protein antibody; Mitotic spindle-associated protein p126 antibody; SPAG 5 antibody; SPAG5 antibody; SPAG5_ antibody; Sperm associated antigen 5 antibody; Sperm tail protein Spag 5 antibody; Sperm tail protein Spag5 antibody; Sperm-associated antigen 5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96R06 Immunogen:Recombinant Sperm-associated antigen 5 protein (1-300AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubµLe-kinetochore attachments. May contribute to the regµLation of separase activity. May regµLate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granµLes (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SPAG5 Research Areas:Cell biology