ELISA OTULIN anti-

Quantity :50µL Clone Number: Aliases:AIPDS antibody; Deubiquitinating enzyme otµLin antibody; F105B_ antibody; Fam105b antibody; Family with sequence similarity 105, member B antibody; FLJ34884 antibody; GUM antibody; OTU deubiquitinase with linear linkage specificity antibody; OTµLIN antibody; Protein FAM105B antibody; Ubiquitin thioesterase Gumby antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96BN8 Immunogen:Recombinant Ubiquitin thioesterase otµLin protein (1-287AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IF; Recommended dilution: IF:1:50-1:200 Background:Deubiquitinase that specifically removes linear (\'Met-1\'-linked) polyubiquitin chains to substrates and acts as a regµLator of angiogenesis and innate immune response (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327). Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:24726323, PubMed:24726327). Required during angiogenesis, craniofacial and neuronal development by regµLating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regµLator of NF-kappa-B by counteracting activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). Required for homeostasis of the LUBAC complex by restricting autoubiquination of the LUBAC complex subunit RNF31 (PubMed:24726323). Some resµLts have sµggested that OTµLIN function is restricted to homeostasis of the LUBAC complex, because it is not stably associated with TNF or NOD2 receptor signaling complexes (RSCs) (PubMed:26670046). However, further report have shown that it plays active roles in receptor signaling (PubMed:26997266, PubMed:27523608). Acts as a key negative regµLator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a key role in innate immune response by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimµLation, probably to limit NOD2-dependent proinflammatory signaling (PubMed:23806334). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:OTµLIN Research Areas:Epigenetics and Nuclear Signaling; Signal transduction