ELISA TSEN2 anti-

Quantity :50µL Clone Number: Aliases:HsSen2 antibody; MGC2776 antibody; MGC4440 antibody; SEN2 antibody; SEN2_ antibody; SEN2L antibody; tRNA intron endonuclease Sen2 antibody; tRNA splicing endonuclease 2 homolog (SEN2; S. cerevisiae) antibody; tRNA splicing endonuclease subunit Sen2 antibody; tRNA-intron endonuclease sen2 antibody; tRNA-splicing endonuclease subunit Sen2 antibody; TSEN 2 antibody; TSEN2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8NCE0 Immunogen:Recombinant tRNA-splicing endonuclease subunit Sen2 protein (1-220AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:50-1:200 Background:Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5\\\'- and 3\\\'-splice sites to release the intron. The products are an intron and two tRNA half-molecµLes bearing 2\\\',3\\\'-cyclic phosphate and 5\\\'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5\\\'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3\\\'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3\\\'-end formation, sµggesting that the endonuclease subunits function in mµLtiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, althoµgh it retains endonucleolytic activity. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TSEN2 Research Areas:Epigenetics and Nuclear Signaling; Cell biology