ELISA SPPL3 anti-

Quantity :50µg Clone Number: Aliases:SPPL3 antibody; IMP2 antibody; PSL4 antibody; Signal peptide peptidase-like 3 antibody; SPP-like 3 antibody; EC 3.4.23.- antibody; Intramembrane protease 2 antibody; IMP-2 antibody; Presenilin homologous protein 1 antibody; PSH1 antibody; Presenilin-like protein 4 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8TCT6 Immunogen:Recombinant Signal peptide peptidase-like 3 protein (213-263AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IF; Recommended dilution: WB:1:200-1:2000, IF:1:50-1:200 Background:Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regµLation of cellµLar glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SPPL3 Research Areas:Cell biology