ELISA TET1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:bA119F7.1 antibody; CXXC 6 antibody; CXXC finger 6 antibody; CXXC type zinc finger protein 6 antibody; CXXC zinc finger 6 antibody; CXXC-type zinc finger protein 6 antibody; CXXC6 antibody; KIAA1676 antibody; LCX antibody; Leukemia associated protein with a CXXC domain antibody; Leukemia-associated protein with a CXXC domain antibody; Methylcytosine dioxygenase TET1 antibody; Ten eleven translocation 1 antibody; Ten eleven translocation 1 gene protein antibody; Ten eleven translocation 1 gene protein homolog antibody; Ten-eleven translocation 1 gene protein antibody; Tet 1 antibody; Tet methylcytosine dioxygenase 1 antibody; Tet oncogene 1 antibody; TET1 antibody; TET1_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8NFU7 Immunogen:Recombinant Methylcytosine dioxygenase TET1 protein (1700-1800AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regµLation. In addition to its role in DNA demethylation, plays a more general role in chromatin regµLation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes throµgh recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an important role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TET1 Research Areas:Epigenetics and Nuclear Signaling; Cancer