ELISA BBS5 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Bardet Biedl syndrome 5 protein antibody; Bardet-Biedl syndrome 5 protein antibody; BBS5 antibody; BBS5_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8N3I7 Immunogen:Recombinant Bardet-Biedl syndrome 5 protein (224-317AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:The BBSome complex is thoµght to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regµLation. Required for BBSome complex ciliary localization but not for the proper complex assembly. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BBS5 Research Areas: