ELISA SKA1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:2810433K01Rik antibody; AV117428 antibody; C18orf24 antibody; MGC10200 antibody; Ska1 antibody; SKA1_ antibody; Spindle and kinetochore associated complex subunit 1 antibody; Spindle and kinetochore associated protein 1 antibody; Spindle and kinetochore-associated protein 1 antibody; Spindle and KT (kinetochore) associated 1 antibody; Spindle and KT associated 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96BD8 Immunogen:Recombinant Spindle and kinetochore-associated protein 1 protein (61-134AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Component of the SKA1 complex, a microtubµLe-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubµLes leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubµLe interface and directly associates with microtubµLes as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubµLe in a depolymerization-coupled manner (PubMed:19289083). Affinity for microtubµLes is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubµLes (PubMed:23085020). In the complex, it mediates the interaction with microtubµLes (PubMed:19289083, PubMed:23085020). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SKA1 Research Areas:Cell biology