ELISA DDB2 Antibody, HRP

Quantity :50µg Clone Number: Aliases:damage-specific DNA binding protein 2 antibody; Damage-specific DNA-binding protein 2 antibody; DDB p48 subunit antibody; Ddb2 antibody; DDB2_ antibody; DDBb antibody; DNA damage-binding protein 2 antibody; UV-damaged DNA-binding protein 2 antibody; UV-DDB 2 antibody; Xeroderma pigmentosum group E protei antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q92466 Immunogen:Recombinant DNA damage-binding protein 2 protein (1-185AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition modµLe for the DCX (DDB1-CµL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CµL4-ROC1 (also known as CµL4-DDB-ROC1 and CµL4-DDB-RBX1). The DDB1-CµL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CµL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DDB2 Research Areas:Epigenetics and Nuclear Signaling; Cancer