ELISA UBE2W Antibody, Biotin

Quantity :50µg Clone Number: Aliases:FLJ11011 antibody; hUBC 16 antibody; hUBC16 antibody; Probable ubiquitin conjµgating enzyme E2 W antibody; Probable ubiquitin-conjµgating enzyme E2 W antibody; UBC 16 antibody; UBC-16 antibody; UBC16 antibody; UBE 2W antibody; ube2w antibody; UBE2W_ antibody; Ubiquitin carrier protein W antibody; Ubiquitin conjµgating enzyme 16 antibody; Ubiquitin conjµgating enzyme E2 W antibody; Ubiquitin conjµgating enzyme E2W antibody; Ubiquitin protein ligase W antibody; Ubiquitin-protein ligase W antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96B02 Immunogen:Recombinant Ubiquitin-conjµgating enzyme E2 W protein (1-151AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjµgating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes \'Lys-11\'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:UBE2W Research Areas:Epigenetics and Nuclear Signaling; Cell biology