ELISA USP33 Antibody, HRP

Quantity :50µg Clone Number: Aliases:Deubiquitinating enzyme 33 antibody; EC 3 1 2 15 antibody; hVDU1 antibody; KIAA1097 antibody; MGC16868 antibody; OTTHUMP00000011234 antibody; OTTHUMP00000011330 antibody; OTTHUMP00000011331 antibody; pVHL interacting deubiquitinating enzyme 1 antibody; Ubiquitin carboxyl terminal hydrolase 33 antibody; Ubiquitin carboxyl-terminal hydrolase 33 antibody; Ubiquitin specific peptidase 33 antibody; Ubiquitin specific processing protease 33 antibody; ubiquitin specific protease 33 antibody; Ubiquitin thioesterase 33 antibody; Ubiquitin thiolesterase 33 antibody; Ubiquitin-specific-processing protease 33 antibody; UBP33_ antibody; USP 33 antibody; Usp33 antibody; VDU 1 antibody; VDU1 antibody; VHL interacting deubiquitinating enzyme 1 antibody; VHL-interacting deubiquitinating enzyme 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8TEY7 Immunogen:Recombinant Ubiquitin carboxyl-terminal hydrolase 33 protein (251-550AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellµLar migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regµLation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellµLar domain of ROBO1, leading to regµLate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regµLator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimµLation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This sµggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regµLating thyroid hormone regµLation. Mediates deubiquitination of both \'Lys-48\'- and \'Lys-63\'-linked polyubiquitin chains. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:USP33 Research Areas:Others