ELISA TRIB1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:C8FW antibody; G-protein-coupled receptor-induced gene 2 protein antibody; GIG-2 antibody; GIG2 antibody; SKIP1 antibody; TRB-1 antibody; TRB1 antibody; Trib1 antibody; TRIB1_ antibody; Tribbles homolog 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96RU8 Immunogen:Recombinant Tribbles homolog 1 protein (3-91AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596). The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). RegµLates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regµLates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TRIB1 Research Areas:CardiovascµLar; Metabolism; Signal transduction; Stem cells