ELISA NSMCE2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:C8orf36 antibody; E3 SUMO-protein ligase NSE2 antibody; hMMS21 antibody; hNSE2 antibody; methyl methanesµLfonate sensitivity gene 21 antibody; MMS21 antibody; MMS21 homolog antibody; non-SMC element 2 antibody; Non-SMC element 2 homolog antibody; Non-structural maintenance of chromosomes element 2 homolog antibody; NSE2 antibody; NSE2_ antibody; Nsmce2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96MF7 Immunogen:Recombinant E3 SUMO-protein ligase NSE2 protein (1-247AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PmL bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PmL nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NSMCE2 Research Areas:Epigenetics and Nuclear Signaling; Cell biology