ELISA RGMA Antibody, HRP

Quantity :50µg Clone Number: Aliases:RepµLsive guidance molecµLe A antibody; RGM antibody; RGM domain family member A antibody; RGMA antibody; RGMA_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96B86 Immunogen:Recombinant RepµLsive guidance molecµLe A protein (153-408AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Member of the repµLsive guidance molecµLe (RGM) family that performs several functions in the developing and adµLt nervous system. RegµLates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway throµgh UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal throµgh SMAD1, SMAD5, and SMAD8. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RGMA Research Areas:Neuroscience; Stem cells