ELISA SUPT16H Antibody, FITC

Quantity :50µg Clone Number: Aliases:CDC68 antibody; Chromatin specific transcription elongation factor 140 kDa subunit antibody; Chromatin-specific transcription elongation factor 140 kDa subunit antibody; Facilitates chromatin transcription complex subunit SPT16 antibody; FACT 140 kDa subunit antibody; FACT antibody; FACT complex subunit SPT16 antibody; FACTp140 antibody; FLJ10857 antibody; FLJ14010 antibody; hSPT16 antibody; SP16H_ antibody; Suppressor of Ty 16 homolog antibody; Supt16h antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9Y5B9 Immunogen:Recombinant FACT complex subunit SPT16 protein (187-282AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in mµLtiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of \'Ser-392\' of p53/TP53 via its association with CK2 (casein kinase II). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SUPT16H Research Areas:Epigenetics and Nuclear Signaling; Cell biology; Signal transduction