ELISA SPPL2B Antibody, Biotin

Quantity :50µg Clone Number: Aliases:SPPL2B antibody; IMP4 antibody; KIAA1532 antibody; PSL1 antibody; Signal peptide peptidase-like 2B antibody; SPP-like 2B antibody; SPPL2b antibody; EC 3.4.23.- antibody; Intramembrane protease 4 antibody; IMP-4 antibody; Presenilin homologous protein 4 antibody; PSH4 antibody; Presenilin-like protein 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8TCT7 Immunogen:Recombinant Signal peptide peptidase-like 2B protein (492-592AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellµLar domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regµLation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SPPL2B Research Areas:Others