ELISA TRPV1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:Capsaicin receptor antibody; DKFZp434K0220 antibody; osm 9 like TRP channel 1 antibody; Osm-9-like TRP channel 1 antibody; OTRPC1 antibody; Transient receptor potential cation channel subfamily V member 1 antibody; TRPV 1 antibody; Trpv1 antibody; TRPV1_ antibody; Vanilloid receptor 1 antibody; Vanilloid receptor subtype 1 antibody; VR 1 antibody; VR1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8NER1 Immunogen:Recombinant Transient receptor potential cation channel subfamily V member 1 protein (1-155AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimµLi. Seems to mediate proton influx and may be involved in intracellµLar acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellµLar acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodµLatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TRPV1 Research Areas:Neuroscience