ELISA SIRT2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:FLJ35621 antibody; FLJ37491 antibody; NAD dependent deacetylase sirtuin 2 antibody; NAD dependent protein deacetylase sirtuin 2 antibody; NAD-dependent deacetylase sirtuin-2 antibody; NAD-dependent protein deacetylase sirtuin-2 antibody; RegµLatory protein SIR2 homolog 2 antibody; Silencing information regµLator 2 like antibody; Silent information regµLator 2 antibody; SIR2 antibody; SIR2 like protein 2 antibody; Sir2 related protein type 2 antibody; SIR2, S. cerevisiae, homolog-loke 2 antibody; SIR2-like protein 2 antibody; SIR2L antibody; SIR2L2 antibody; SIRT2 antibody; SIRT2_ antibody; Sirtuin (silent mating type information regµLation 2 homolog) 2 (S.cerevisiae) antibody; Sirtuin 2 antibody; Sirtuin type 2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8IXJ6 Immunogen:Recombinant NAD-dependent protein deacetylase sirtuin-2 protein (177-279AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubµLin as well as many other proteins such as key transcription factors. Participates in the modµLation of mµLtiple and diverse biological processes such as cell cycle control, genomic integrity, microtubµLe dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubµLe stress agents, and hence allowing proper inheritance of chromosomes. Positively regµLates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression throµgh mitosis. Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction throµgh epigenetic modµLation of the regµLation of histone H4 \\\'Lys-20\\\' methylation (H4K20me1) during early mitosis. Specifically deacetylates histone H4 at \\\'Lys-16\\\' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to µLterior levels of H4K20me2 and H4K20me3 deposition throµghout cell cycle, and mitotic S-phase progression. Deacetylates KMT5A modµLating KMT5A chromatin localization during the mitotic stress response. Deacetylates also histone H3 at \\\'Lys-57\\\' (H3K56ac) during the mitotic G2/M transition. Upon bacterium Listeria monocytogenes infection, deacetylates \\\'Lys-18\\\' of histone H3 in a receptor tyrosine kinase MET- and PI3K/Akt-dependent manner, thereby inhibiting transcriptional activity and promoting late stages of listeria infection. During oocyte meiosis progression, may deacetylate histone H4 at \\\'Lys-16\\\' (H4K16ac) and alpha-tubµLin, regµLating spindle assembly and chromosome alignment by influencing microtubµLe dynamics and kinetochore function. Deacetylates alpha-tubµLin at \\\'Lys-40\\\' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells. Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubµLin deacetylation, negatively regµLating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Deacetylates PARD3 and participates in the regµLation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination. Involved in several cellµLar metabolic pathways. Plays a role in the regµLation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability. Acts as a key regµLator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimµLates the production of cytosolic NADPH to counteract oxidative damage. Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis. Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity. Plays a role in the regµLation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells. Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regµLating FOXO1-mediated autophagy. Deacetylates a broad range of transcription factors and co-regµLators regµLating target gene expression. Deacetylates transcriptional factor FOXO3 stimµLating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation. Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia. Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimµLation. Inhibits transcriptional activation by deacetylating p53/TP53 and EP300. Deacetylates also EIF5A. Functions as a negative regµLator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions. Plays a role as tumor suppressor. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SIRT2 Research Areas:Epigenetics and Nuclear Signaling; Signal transduction