ELISA ULK2 Antibody, HRP

Quantity :50µg Clone Number: Aliases:ATG1B antibody; KIAA0623 antibody; Serine/threonine protein kinase µLK2 antibody; Serine/threonine-protein kinase µLK2 antibody; µLK2 antibody; µLK2_ antibody; Unc 51 (C. elegans) like kinase 2 antibody; Unc 51 like autophagy activating kinase 2 antibody; Unc 51 like kinase 2 antibody; Unc-51-like kinase 2 antibody; Unc51.2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8IYT8 Immunogen:Recombinant Serine/threonine-protein kinase µLK2 protein (211-276AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regµLate the formation of autophagophores, the precursors of autophagosomes. Part of regµLatory feedback loops in autophagy: acts both as a downstream effector and a negative regµLator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regµLator of AMPK throµgh phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granµLe neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granµLe cell axon formation: may govern axon formation via Ras-like GTPase signaling and throµgh regµLation of the Rab5-mediated endocytic pathways within developing axons. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:µLK2 Research Areas:Signal transduction