ELISA SMC5 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:SMC5 antibody; KIAA0594 antibody; SMC5L1 antibody; Structural maintenance of chromosomes protein 5 antibody; SMC protein 5 antibody; SMC-5 antibody; hSMC5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8IY18 Immunogen:Recombinant Structural maintenance of chromosomes protein 5 protein (296-403AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PmL bodies (APBs). Required for recruitment of telomeres to PmL nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circµLar viral DNA genome (PubMed:26983541). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SMC5 Research Areas:Epigenetics and Nuclear Signaling; Cell biology