ELISA SYVN1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:1200010C09Rik antibody; DER3 antibody; E3 ubiquitin-protein ligase synoviolin antibody; HMG coA reductase degradation 1 homolog antibody; HRD1 antibody; KIAA1810 antibody; MGC40372 antibody; OTTHUMP00000230429 antibody; OTTHUMP00000230430 antibody; OTTHUMP00000230431 antibody; OTTHUMP00000230432 antibody; Synovial apoptosis inhibitor 1 antibody; Synovial apoptosis inhibitor 1; synoviolin antibody; Synoviolin 1 antibody; Synoviolin 1 isoform b antibody; SYNOVIOLIN antibody; SYVN1 antibody; SYVN1_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q86TM6 Immunogen:Recombinant E3 ubiquitin-protein ligase synoviolin protein (338-487AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticµLum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticµLum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticµLum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regµLating its biological function in transcription, cell cycle regµLation and apoptosis. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SYVN1 Research Areas:Epigenetics and Nuclear Signaling; Cell biology