ELISA STK36 anti-

Quantity :100µL Clone Number: Aliases:FU antibody; Fused homolog antibody; KIAA1278 antibody; Serine/threonine kinase 36, fused homolog antibody; Serine/threonine protein kinase 36 fused homolog antibody; Serine/threonine-protein kinase 36 antibody; STK36 antibody; STK36_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NRP7 Immunogen:SyntheQuantityd peptide derived from internal of STK36. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regµLating the activity of GLI transcription factors. Controls the activity of the transcriptional regµLators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regµLating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. Murone M., Nat. Cell Biol. 2:310-312(2000). Nagase T., DNA Res. 6:337-345(1999). Hillier L.W., Nature 434:724-731(2005). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:STK36 Research Areas:Cancer;Cell biology;Signal transduction