ELISA SMC1A (Ab-957) anti-

Quantity :100µL Clone Number: Aliases:Chromosome segregation protein SmcB antibody; DXS423E antibody; KIAA0178 antibody; MGC138332 antibody; Sb1.8 antibody; Segregation of mitotic chromosomes 1 antibody; SMC protein 1A antibody; SMC-1-alpha antibody; SMC-1A antibody; SMC1 (structural maintenance of chromosomes 1 yeast) like 1 antibody; SMC1 antibody; SMC1 structural maintenance of chromosomes 1 like 1 antibody; SMC1A antibody; SMC1A_ antibody; SMC1alpha antibody; SMC1L1 antibody; SMCB antibody; Structural maintenance of chromosomes 1A antibody; Structural maintenance of chromosomes protein 1A antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q14683 Immunogen:Peptide sequence around aa. 955~959 (G-S-S-Q-G) derived from SMC1. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:200 Background:Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. Yang XM. et al. (2004) Mol Cell Biol. 24(12): 5290-5303. Kim ST. et al. (2002) Genes Dev. 16(5): 560-570. Revenkova E.et al. (2001) Mol Cell Biol. 21(20): 6984-6998 Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SMC1A Research Areas:Epigenetics and Nuclear Signaling;Cell biology