ELISA TICAM2 anti-

Quantity :50µL Clone Number: Aliases:Putative NF-kappa-B-activating protein 502 antibody; TCAM2_ antibody; TICAM-2 antibody; TICAM2 antibody; TIR containing adapter molecµLe 2 antibody; TIR domain containing adaptor protein antibody; TIR domain-containing adapter molecµLe 2 antibody; TIRAP 3 antibody; TIRAP3 antibody; TIRAP3a short form antibody; TIRP antibody; Toll-like receptor adaptor protein 3 antibody; Toll/interleukin-1 receptor domain-containing protein antibody; TRAM antibody; TRIF-related adapter molecµLe antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q86XR7 Immunogen:Recombinant TIR domain-containing adapter molecµLe 2 protein (1-235AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Functions as sorting adapter in LPS-TLR4 signaling to regµLate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TICAM2 Research Areas:Immunology