ELISA THOC6 Antibody, HRP

Quantity :50µL Clone Number: Aliases:THOC6 antibody; WDR58 antibody; PSEC0006 antibody; THO complex subunit 6 homolog antibody; Functional spliceosome-associated protein 35 antibody; fSAP35 antibody; WD repeat-containing protein 58 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q86W42 Immunogen:Recombinant THO complex subunit 6 homolog protein (56-315AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Acts as component of the THO subcomplex of the TREX complex which is thoµght to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5\' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi\'s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:THOC6 Research Areas:Cell biology