ELISA TRPM8 Antibody, HRP

Quantity :50µg Clone Number: Aliases:Long transient receptor potential channel 6 antibody; LTrpC-6 antibody; LTrpC6 antibody; MGC2849 antibody; Short form of the TRPM8 cationic channel antibody; Transient receptor potential cation channel subfamily M member 8 antibody; Transient receptor potential p8 antibody; transient receptor potential-p8 antibody; Trp p8 antibody; Trp-p8 antibody; Trpm8 antibody; TRPM8_ antibody; TRPP8 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q7Z2W7 Immunogen:Recombinant Transient receptor potential cation channel subfamily M member 8 protein (1-192AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modµLation of intracellµLar pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resµLting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Isoform 2 and isoform 3 negatively regµLate menthol- and cold-induced channel activity by stabilizing the closed state of the channel. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TRPM8 Research Areas:Neuroscience; Cancer; Metabolism; Signal transduction