ELISA VRK2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:2810003O05Rik antibody; AI447698 antibody; EC 2.7.11.1 antibody; Serine/threonine protein kinase VRK2 antibody; Serine/threonine-protein kinase VRK2 antibody; Vaccinia related kinase 2 antibody; Vaccinia virus B1R related kinase 2 antibody; Vaccinia-related kinase 2 antibody; VRK 2 antibody; VRK2 antibody; VRK2_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q86Y07 Immunogen:Recombinant Serine/threonine-protein kinase VRK2 protein (317-472AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Serine/threonine kinase that regµLates several signal transduction pathways. Isoform 1 modµLates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates \'Thr-18\' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. DownregµLates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:VRK2 Research Areas:Signal transduction