ELISA USP30 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Deubiquitinating enzyme 30 antibody; FLJ40511 antibody; Ub-specific protease 30 antibody; Ubiquitin carboxyl terminal hydrolase 30 antibody; Ubiquitin carboxyl-terminal hydrolase 30 antibody; Ubiquitin specific peptidase 30 antibody; Ubiquitin specific processing protease 30 antibody; Ubiquitin thioesterase 30 antibody; Ubiquitin thiolesterase 30 antibody; Ubiquitin-specific-processing protease 30 antibody; UBP30_ antibody; usp30 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q70CQ3 Immunogen:Recombinant Ubiquitin carboxyl-terminal hydrolase 30 protein (101-400AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin\'s ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves \'Lys-6\'- and \'Lys-11\'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at \'Ser-65\' (PubMed:25527291). Acts as negative regµLator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:USP30 Research Areas:Epigenetics and Nuclear Signaling; Cell biology; Metabolism; Signal transduction