ELISA OTUD7B Antibody, FITC

Quantity :50µg Clone Number: Aliases:CellµLar zinc finger anti NF kappa B protein antibody; CellµLar zinc finger anti-NF-kappa-B protein antibody; CEZANNE antibody; HGNC:16683 antibody; OTU domain containing protein 7B antibody; OTU domain-containing protein 7B antibody; OTU7B_ antibody; OTUD7B antibody; ZA20D1 antibody; Zinc finger A20 domain containing protein 1 antibody; Zinc finger A20 domain-containing protein 1 antibody; Zinc finger protein Cezanne antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q6GQQ9 Immunogen:Recombinant OTU domain-containing protein 7B protein (235-347AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Negative regµLator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regµLator of B-cell responses. In response to non-canonical NF-kappa-B stimµLi, deubiquitinates \'Lys-48\'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regµLates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regµLates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward \'Lys-11\', \'Lys-48\' and \'Lys-63\'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with \'Lys-11\'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:OTUD7B Research Areas:Epigenetics and Nuclear Signaling; Cell biology; Signal transduction