ELISA ULK3 anti-

Quantity :50µL Clone Number: Aliases:DKFZP434C131 antibody; FLJ90566 antibody; Serine/threonine-protein kinase µLK3 antibody; µLk3 antibody; µLK3_ antibody; unc 51 like kinase 3 (C. elegans) antibody; Unc-51-like kinase 3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q6PHR2 Immunogen:Recombinant Serine/threonine-protein kinase µLK3 protein (44-240AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Serine/threonine protein kinase that acts as a regµLator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regµLator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regµLates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, althoµgh less efficiently. Also acts as a regµLator of autophagy: following cellµLar senescence, able to induce autophagy. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:µLK3 Research Areas:Signal transduction