ELISA TYROBP anti-

Quantity :50µL Clone Number: Aliases:DAP 12 antibody; DAP12 antibody; DNAX activation protein 12 antibody; DNAX-activation protein 12 antibody; KAR-associated protein antibody; KARAP antibody; Killer activating receptor associated protein antibody; Killer-activating receptor-associated protein antibody; PLOSL antibody; TYOBP_ antibody; TYRO protein tyrosine kinase binding protein antibody; TYRO protein tyrosine kinase-binding protein antibody; TYROBP antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O43914 Immunogen:Synthetic peptide of TYROBP Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, IHC; ELISA:1:1000-1:10000, IHC:1:25-1:100 Background:This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. MµLtiple alternative transcript variants encoding distinct isoforms have been identified for this gene. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TYROBP Research Areas:Signal transduction