ELISA STAT1 anti-

Quantity :100µL Clone Number: Aliases:Signal transducer and activator of transcription 1 91kD antibody; CANDF7 antibody; DKFZp686B04100 antibody; IMD31A antibody; IMD31B antibody; IMD31C antibody; ISGF 3 antibody; ISGF-3 antibody; OTTHUMP00000163552 antibody; OTTHUMP00000165046 antibody; OTTHUMP00000165047 antibody; OTTHUMP00000205845 antibody; Signal transducer and activator of transcription 1 91kDa antibody; Signal transducer and activator of transcription 1 antibody; Signal transducer and activator of transcription 1, 91kD antibody; Signal transducer and activator of transcription 1-alpha/beta antibody; STAT 1 antibody; Stat1 antibody; STAT1_ antibody; STAT91 antibody; Transcription factor ISGF 3 components p91 p84 antibody; Transcription factor ISGF-3 components p91/p84 antibody; Transcription factor ISGF3 components p91/p84 antibody; XStat1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P42224 Immunogen:SyntheQuantityd peptide derived from internal of STAT1. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Signal transducer and transcription activator that mediates cellµLar responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimµLated response element (ISRE) to activate the transcription of IFN-stimµLated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellµLar antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellµLar responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Schindler C., Proc. Natl. Acad. Sci. U.S.A. 89:7836-7839(1992). Hillier L.W., Nature 434:724-731(2005). Yan R., Nucleic Acids Res. 23:459-463(1995). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:STAT1 Research Areas:Epigenetics and Nuclear Signaling;Cancer;Signal transduction