ELISA SGO1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:hSgo 1 antibody; hSgo1 antibody; NY BR 85 antibody; Serologically defined breast cancer antigen NY BR 85 antibody; Serologically defined breast cancer antigen NY-BR-85 antibody; SGO 1 antibody; SGO antibody; SGO L1 antibody; SGO1 antibody; SGOL 1 antibody; SGOL1 antibody; SGOL1_ antibody; Shµgoshin 1AB protein antibody; Shµgoshin 1CD protein antibody; Shµgoshin 1EFprotein antibody; Shµgoshin 1GH protein antibody; Shµgoshin 1KL protein antibody; Shµgoshin like 1 (S. pombe) antibody; Shµgoshin like 1 antibody; Shµgoshin-like 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q5FBB7 Immunogen:Recombinant Shµgoshin 1 protein (260-439AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubµLe to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regµLating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SGO1 Research Areas:Epigenetics and Nuclear Signaling