ELISA ACKR1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:ACKR1 antibody; Atypical chemokine receptor 1 antibody; CCBP1 antibody; CD234 antibody; DARC antibody; Dfy antibody; Duffy antigen/chemokine receptor antibody; duffy blood group antibody; Duffy blood group antigen antibody; Duffy blood group chemokine receptor antibody; DUFFY_ antibody; FY antibody; Fy glycoprotein antibody; Glycoprotein D antibody; GPD antibody; GpFy antibody; Plasmodium vivax receptor antibody; WBCQ1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q16570 Immunogen:Recombinant Atypical chemokine receptor 1 protein (1-63AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resµLting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regµLate chemokine bioavailability and, consequently, leukocyte recruitment throµgh two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circµLating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ACKR1 Research Areas:CardiovascµLar; Immunology; Microbiology; Signal transduction