ELISA SMARCB1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:BAF47 antibody; BRG1-associated factor 47 antibody; hSNF5 antibody; INI1 antibody; Integrase interactor 1 protein antibody; Malignant rhabdoid tumor suppressor antibody; RDT antibody; RTPS1 antibody; Sfh1p antibody; SMARCB1 antibody; SNF5 homolog antibody; SNF5_ antibody; SNF5L1 antibody; Snr1 antibody; Sucrose nonfermenting yeast homolog like 1 antibody; SWI/SNF complex component SNF5 antibody; SWI/SNF-related matrix-associated actin-dependent regµLator of chromatin subfamily B member 1 antibody; SWI10 antibody; Transcription factor TYE4 antibody; Transcription regµLatory protein SNF5 antibody; TYE4 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q12824 Immunogen:Recombinant SWI/SNF-related matrix-associated actin-dependent regµLator of chromatin subfamily B member 1 protein (2-376AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellµLar antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling woµLd be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. StimµLates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adµLt state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the mµLtipotent neural stem cells. The nBAF complex along with CREST plays a role regµLating the activity of genes essential for dendrite growth By similarity. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Also involved in vitamin D-coupled transcription regµLation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SMARCB1 Research Areas:Epigenetics and Nuclear Signaling; Cancer