ELISA TARBP2 anti-

Quantity :50µL Clone Number: Aliases:LOQS antibody; Prbp antibody; RISC loading complex subunit TARBP2 antibody; RISC-loading complex subunit tarbp2 antibody; TAR (HIV 1) RNA binding protein 2 antibody; TAR (HIV) RNA binding protein 2 antibody; TAR (HIV) RNA-binding protein TRBP1 antibody; TAR RNA Binding Protein 2 antibody; TAR RNA-binding protein 2 antibody; tarbp2 antibody; TARBP2 RISC loading complex RNA binding subunit antibody; Trans-activation-responsive RNA-binding protein antibody; TRBP antibody; TRBP1 antibody; TRBP2 antibody; TRBP2_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q15633 Immunogen:Recombinant RISC-loading complex subunit TARBP2 protein (1-366AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimµLates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TARBP2 Research Areas:Epigenetics and Nuclear Signaling; Microbiology