ELISA TNIP1 anti-

Quantity :50µg Clone Number: Aliases:ABIN 1 antibody; HIV-1 Nef-interacting protein antibody; hVAN antibody; KIAA0113 antibody; Naf1 antibody; Nef-associated factor 1 antibody; Nip40-1 antibody; TNFAIP3 interacting protein 1 antibody; TNFAIP3-interacting protein 1 antibody; TNIP-1 antibody; Tnip1 antibody; TNIP1_ antibody; VAN antibody; Virion-associated nuclear shuttling protein antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q15025 Immunogen:Recombinant TNFAIP3-interacting protein 1 protein (526-636AA) Raised in:Rabbit Reactivity:, Rat Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200 Background:Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regµLating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regµLation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regµLates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regµLate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TNIP1 Research Areas:Immunology; Signal transduction