ELISA SMN1 anti-

Quantity :50µg Clone Number: Aliases:BCD541 antibody; Component of gems 1 antibody; Gemin 1 antibody; Gemin-1 antibody; OTTHUMP00000125198 antibody; OTTHUMP00000223567 antibody; OTTHUMP00000223568 antibody; OTTHUMP00000224066 antibody; OTTHUMP00000226924 antibody; SMA 1 antibody; SMA 2 antibody; SMA 3 antibody; SMA 4 antibody; SMA antibody; SMA@ antibody; SMA1 antibody; SMA2 antibody; SMA3 antibody; SMA4 antibody; SMN antibody; SMN_ antibody; SMN1 antibody; SMN2 antibody; SMNT antibody; Survival motor neuron protein antibody; Survival of motor neuron 1, telomeric antibody; T-BCD541 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q16637 Immunogen:Recombinant Survival motor neuron protein (3-194AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 Background:The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellµLar pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SMN1 Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Signal transduction