ELISA SKP2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:CDK2/Cyclin A associated protein p45 antibody; Cyclin A/CDK2 associated protein p45 antibody; Cyclin-A/CDK2-associated protein p45 antibody; F box protein Skp2 antibody; F box/LRR repeat protein 1 antibody; F-box protein Skp2 antibody; F-box/LRR-repeat protein 1 antibody; FBL 1 antibody; FBL1 antibody; FBXL 1 antibody; FBXL1 antibody; FLB 1 antibody; FLB1 antibody; MGC1366 antibody; p45 antibody; p45skp2 antibody; S phase kinase associated protein 2 (p45) antibody; S phase kinase associated protein 2 antibody; S-phase kinase-associated protein 2 antibody; S-phase kinase-associated protein 2 E3 ubiquitin protein ligase antibody; SKP 2 antibody; Skp2 antibody; SKP2_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13309 Immunogen:Recombinant S-phase kinase-associated protein 2 protein (1-424AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Substrate recognition component of a SCF (SKP1-CµL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regµLation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/mLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regµLating cell migration. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SKP2 Research Areas:Cancer; CardiovascµLar; Cell biology