ELISA PIAS4 anti-

Quantity :100µL Clone Number: Aliases:E3 SUMO protein ligase PIAS4 antibody; E3 SUMO-protein ligase PIAS4 antibody; FLJ12419 antibody; MGC35296 antibody; PAIASgamma antibody; PIAS 4 antibody; PIAS gamma antibody; PIAS-gamma antibody; Pias4 antibody; PIAS4_ antibody; PIASG antibody; PIASgamma antibody; PIASy antibody; Protein inhibitor of activated STAT 4 antibody; Protein inhibitor of activated STAT protein 4 antibody; Protein inhibitor of activated STAT protein gamma antibody; Protein inhibitor of activated STAT protein PIASy antibody; Zinc finger MIZ type containing 6 antibody; ZMIZ 6 antibody; ZMIZ6 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8N2W9 Immunogen:SyntheQuantityd peptide derived from Internal of PIAS4. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregµLation in various cellµLar pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities throµgh promoting their sumoylations. Zendra E. Zehner, AACR Meeting Abstracts, Apr 2005; 2005: 456. Amador Albor, J. Biol. Chem., Sep 2006; 281: 25850 - 25866. Christina-Maria Hecker, J. Biol. Chem., Jun 2006; 281: 16117 - 16127. Yun Zhao, Stem Cells, Apr 2007; 10.1634. Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PIAS4 Research Areas:Epigenetics and Nuclear Signaling