ELISA SYK (Ab-323) anti-

Quantity :100µL Clone Number: Aliases:EC 2.7.10.2 antibody; kinase Syk antibody; KSYK antibody; KSYK_ antibody; p72-Syk antibody; p72syk antibody; Spleen tyrosine kinase antibody; Syk antibody; Tyrosine protein kinase SYK antibody; Tyrosine-protein kinase SYK antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P43405 Immunogen:Peptide sequence around aa. 321~325 (N-P-Y-E-P) derived from syk. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200 Background:Positive effector of BCR-stimµLated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either throµgh a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or throµgh a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regµLation of intracellµLar calcium ion Zhang, J. et al. (2000) J. Biol. Chem. 275, 35442-35447. Turner, M. et al. (2000) Immunol. Today 21, 148-154. Decker, M. et al. (1998) J. Biol. Chem. 273, 8867-8874. Law, C.L. et al. (1996) Mol. Cell. Biol. 16, 1305-1315. Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SYK Research Areas:CardiovascµLar;Immunology;Signal transduction