ELISA SUV39H2 anti-

Quantity :100µL Clone Number: Aliases:FLJ23414 antibody; H3 K9 HMTase 2 antibody; H3-K9-HMTase 2 antibody; Histone H3 K9 methyltransferase 2 antibody; Histone H3-K9 methyltransferase 2 antibody; Histone lysine N methyltransferase H3 lysine 9 specific 2 antibody; Histone lysine N methyltransferase SUV39H2 antibody; Histone-lysine N-methyltransferase SUV39H2 antibody; KMT1B antibody; Lysine N methyltransferase 1B antibody; Lysine N-methyltransferase 1B antibody; sSuppressor of variegation 3 9 homolog 2 (Drosophila) antibody; Su(var)3 9 Drosophila homolog of 2 antibody; Su(var)3 9 homolog 2 antibody; Su(var)3-9 homolog 2 antibody; Suppressor of variegation 3 9 homolog 2 antibody; Suppressor of variegation 3-9 homolog 2 antibody; Suv39h2 antibody; SUV92_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9H5I1 Immunogen:SyntheQuantityd peptide derived from internal of SUV39H2. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regµLation, transcriptional repression and regµLation of telomere length. May participate in regµLation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state throµgh H3 'Lys-9' trimethylation. Sµgano S., Nat. Genet. 36:40-45(2004). Venter J.C., Submitted (SEP-2005). Schupp I., BMC Genomics 8:399-399(2007). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SUV39H2 Research Areas:Epigenetics and Nuclear Signaling