ELISA TP53 (Ab-46) anti-

Quantity :100µL Clone Number: Aliases:Antigen NY-CO-13 antibody; BCC7 antibody; CellµLar tumor antigen p53 antibody; FLJ92943 antibody; LFS1 antibody; Mutant tumor protein 53 antibody; p53 antibody; p53 tumor suppressor antibody; P53_ antibody; Phosphoprotein p53 antibody; Tp53 antibody; Transformation related protein 53 antibody; TRP53 antibody; tumor antigen p55 antibody; Tumor protein 53 antibody; Tumor protein p53 antibody; Tumor suppressor p53 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P04637 Immunogen:Peptide sequence around aa. 44~48 (M-L-S-P-D) derived from p53. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regµLation as a trans-activator that acts to negatively regµLate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimµLation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Dhavan, R. and Tsai, L.H. (2001) Nat Rev Mol Cell Biol. 2: 749-759. Patrick, G. N. et al. (1998) J Biol Chem. 273: 24057-24064. Di Stefano V, et al. (2005) Oncogene. 24(35):5431-5442. Mayo LD, et al.(2005) J Biol Chem. 280(28):25953-25959. Wang L, et al. (2005) Oncogene. 24(18): 3020-3027. Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TP53 Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology