ELISA vpx Antibody, Biotin

Quantity :50µL Clone Number: Aliases:vpxProtein Vpx antibody; Viral protein X antibody; X ORF protein antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () immunodeficiency virus type 2 subtype A UniProt ID:P06939 Immunogen:Recombinant immunodeficiency virus type 2 subtype A Protein Vpx protein (1-112AA) Raised in:Rabbit Reactivity: immunodeficiency virus type 2 subtype A Tested Applications:ELISA Background:Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellµLar CµL4A-DDB1 E3 ligase complex throµgh direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity resµLts in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellµLar dNTPs necessary for reverse transcription (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:vpx Research Areas:N/A