ELISA LMP2 anti-

Quantity :50µg Clone Number: Aliases:LMP2 antibody; Latent membrane protein 2 antibody; Terminal protein antibody Product Type:Polyclonal Antibody Immunogen Species:Epstein-Barr virus UniProt ID:P13285 Immunogen:Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA) Raised in:Rabbit Reactivity:Epstein-Barr virus Tested Applications:ELISA Background:Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobµLin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecµLar scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobµLin-negative cells to colonize peripheral lymphoid organs. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:LMP2 Research Areas:Others