ELISA MAP2K4 anti-

Quantity :100µL Clone Number: Aliases:c Jun N terminal kinase kinase 1 antibody; C-JUN N-terminal kinase kinase 1 antibody; Dual specificity mitogen activated protein kinase kinase 4 antibody; Dual specificity mitogen-activated protein kinase kinase 4 antibody; JNK Activated Kinase 1 antibody; JNK activating kinase 1 antibody; JNK-activating kinase 1 antibody; JNKK antibody; JNKK1 antibody; MAP kinase kinase 4 antibody; Map2k4 antibody; MAPK ERK kinase 4 antibody; MAPK/ERK kinase 4 antibody; MAPKK 4 antibody; MAPKK4 antibody; MEK 4 antibody; MEK4 antibody; Mitogen activated protein kinase kinase 4 antibody; MKK 4 antibody; MKK4 antibody; MP2K4_ antibody; PRKMK4 antibody; SAPK ERK kinase 1 antibody; SAPK/ERK kinase 1 antibody; SAPKK 1 antibody; SAPKK1 antibody; SEK1 antibody; SERK1 antibody; SKK1 antibody; Stress activated protein kinase kinase 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P45985 Immunogen:SyntheQuantityd peptide derived from internal of JNKK. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimµLi activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. Lin A., Science 268:286-290(1995). Derijard B., Science 267:682-685(1995). Su G.H., Cancer Res. 58:2339-2342(1998). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:MAP2K4 Research Areas:Signal transduction