ELISA TSEN54 anti-

Quantity :100µL Clone Number: Aliases:HsSen54 antibody; PCH2A antibody; PCH4 antibody; sen54 antibody; SEN54 homolog antibody; SEN54_ antibody; SEN54L antibody; tRNA-intron endonuclease SEN54 antibody; tRNA-splicing endonuclease subunit SEN54 antibody; Tsen54 antibody; TSEN54 tRNA splicing endonuclease subunit antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q7Z6J9 Immunogen:SyntheQuantityd peptide derived from internal of TSEN54. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecµLes bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, sµggesting that the endonuclease subunits function in mµLtiple RNA-processing events. Zody M.C., Nature 440:1045-1049(2006). Paushkin S.V., Cell 117:311-321(2004). Ota T., Nat. Genet. 36:40-45(2004). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TSEN54 Research Areas:Epigenetics and Nuclear Signaling