ELISA Phospho-FLT3 (Tyr842) anti-

Quantity :100µL Clone Number: Aliases:CD 135 antibody; CD135 antibody; CD135 antigen antibody; Fetal liver kinase 2 antibody; FL cytokine receptor antibody; Flk 2 antibody; Flk2 antibody; Flt 3 antibody; FLT-3 antibody; Flt3 antibody; FLT3_ antibody; FMS like tyrosine kinase 3 antibody; Fms related tyrosine kinase 3 antibody; Fms-like tyrosine kinase 3 antibody; Growth factor receptor tyrosine kinase type III antibody; Ly-72 antibody; OTTHUMP0000004234 antibody; Receptor type tyrosine protein kinase FLT3 antibody; Stem cell tyrosine kinase 1 antibody; Stk 1 antibody; STK-1 antibody; Stk1 antibody; Tyrosine protein kinase receptor FLT3 antibody; Tyrosine-protein kinase receptor FLT3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P36888 Immunogen:Peptide sequence around phosphorylation site of tyrosine 842(S-N-Y(p)-V-V) derived from FLT3 Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; WB:1:500-1:1000 Background: FLT3 encodes a class III receptor tyrosine kinase that regµLates hematopoiesis. The receptor consists of an extracellµLar domain composed of five immunoglobµLin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellµLar domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates mµLtiple cytoplasmic effector molecµLes in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that resµLt in the constitutive activation of this receptor resµLt in acute myeloid leukemia and acute lymphoblastic leukemia. Small D., Proc. Natl. Acad. Sci. U.S.A. 91:459-463(1994). Rosnet O., Blood 82:1110-1119(1993). Rosnet O., Genomics 9:380-385(1991). Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:FLT3 Research Areas:Immunology;Signal transduction