ELISA SEPT2 anti-

Quantity :100µL Clone Number: Aliases:SEPTIN2 antibody; DIFF6 antibody; KIAA0158 antibody; NEDD5 antibody; SEPT2 antibody; Septin-2 antibody; Neural precursor cell expressed developmentally down-regµLated protein 5 antibody; NEDD-5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q15019 Immunogen:SyntheQuantityd peptide derived from internal of SEPT2. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubµLes, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubµLin. Required for the progression throµgh mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regµLating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellµLar microbial pathogens, Listeria monocytogenes and Shigella flexneri. Nagase T., DNA Res. 2:167-174(1995). Mori T., Cytogenet. Cell Genet. 73:224-227(1996). Ota T., Nat. Genet. 36:40-45(2004). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SEPT2 Research Areas:Cell biology