ELISA TRIM24 anti-

Quantity :100µL Clone Number: Aliases:E3 ubiquitin protein ligase TRIM24 antibody; E3 ubiquitin-protein ligase Trim24 antibody; hTIF1 antibody; PTC6 antibody; RING finger protein 82 antibody; RNF82 antibody; TF1A antibody; TIF1 alpha antibody; TIF1 antibody; TIF1-alpha antibody; TIF1A antibody; TIF1A_ antibody; TIF1ALPHA antibody; Transcription intermediary factor 1-alpha antibody; Transcriptional intermediary factor 1 alpha antibody; Transcriptional intermediary factor 1 antibody; Trim24 antibody; Tripartite motif containing 24 antibody; Tripartite motif-containing protein 24 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O15164 Immunogen:SyntheQuantityd peptide derived from C-terminal of TRIM24. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modµLates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regµLation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regµLates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. ModµLates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regµLating retinoic acid-dependent proliferation of hepatocytes By similarity. Thenot S., J. Biol. Chem. 272:12062-12068(1997). Venturini L., Oncogene 18:1209-1217(1999). Hellal-Levy C., Mol. Endocrinol. 14:1210-1221(2000). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TRIM24 Research Areas:Epigenetics and Nuclear Signaling;Signal transduction