ELISA PODXL Antibody, FITC

Quantity :50µg Clone Number: Aliases:GCTM-2 antigen antibody; Gp2 antibody; Gp200 antibody; MGC138240 antibody; PC antibody; PCLP antibody; PCLP-1 antibody; PCLP1 antibody; Pcx antibody; Podocalyxin antibody; Podocalyxin like antibody; Podocalyxin like protein antibody; Podocalyxin-like protein 1 antibody; Podxl antibody; PODXL_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O00592 Immunogen:Recombinant Podocalyxin protein (32-458AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Involved in the regµLation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecµLe that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repµLsion. Acts as a pro-adhesive molecµLe, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubµLogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion throµgh its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PODXL Research Areas:Cancer; CardiovascµLar; Signal transduction; Stem cells